Smooth muscle tumors of the uterus of uncertain malignant potential

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Uterine smooth-muscle tumors of uncertain malignant potential.

OBJECTIVE To determine whether tumors meeting the criteria of Hendrickson and Kempson for uterine smooth-muscle tumors of uncertain malignant potential have a natural history different from those of leiomyomas and leiomyosarcomas. METHODS Tumors with five to ten mitoses per ten high-power fields and with mild or moderate cellular atypia were classified as tumors of uncertain malignant potenti...

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Potential role of BCL2 in the recurrence of uterine smooth muscle tumors of uncertain malignant potential

Uterine smooth muscle tumors are the most common female genital tract neoplasms. While leiomyosarcoma has been studied at length, smooth muscle tumors of uncertain malignant potential (STUMPs) still have ambiguous and unresolved issues, with a risk of relapse and evolution largely undefined. We performed an array comparative genomic hybridization analysis on a primitive STUMP and its local recu...

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Smooth Muscle Tumors of the Uterus Pathology

The diagnosis of uterine leiomyosarcoma is usually straightforward since most clinically malignant smooth muscle tumors of the uterus show the microscopic constellation of hypercellularity, severe nuclear atypia, and high mitotic rate generally exceeding 15 mitotic figures per 10 high-power-fields (MF/10 HPF). Frequently, one or more supportive clinicopathologic features such as perior postmeno...

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Late presentation of metastatic smooth muscle neoplasm of the uterus with low malignant potential

A 48-year-old woman underwent total abdominal hysterectomy with conservation of the ovaries and tubes. Histology showed a well-circumscribed smooth muscle tumor with foci of degeneration (including infarct-type necrosis) but no coagulative tumor cell necrosis and only mild focal cytological atypia. She presented, 24 years later with shortness of breath and abdominal distension and underwent bil...

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Proposed novel nomenclature of vulvar smooth muscle tumors; a case of Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP) of the vulva

•Clinical experience with smooth muscle tumors of the vulva is limited.•Some tumors present ambiguous histological features concerning for malignancy.•These include infiltration, mitotic activity, size, atypia and tumor cell necrosis.•A case of smooth muscle tumor of the vulva with cellular atypia is presented.•"Smooth Muscle Tumor of Uncertain Malignant Potential" of the vulva is advocated.

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ژورنال

عنوان ژورنال: Onkologie

سال: 2017

ISSN: 1802-4475,1803-5345

DOI: 10.36290/xon.2017.047